5-dodecenoate (12:1n7) to caprate (10:0)

Numerator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Denominator Metabolite

Structure of caprate (10:0)
Metabolite Accession: GCST90200428
Name: caprate (10:0)
Hmdb Id: HMDB0000511
Super Pathway: NA
Sub Pathway: NA
Inchikey: GHVNFZFCNZKVNT

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.164
Position:
102075479
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-8.491
Reference Allele:
G
-log10(P):
-38.424
MAF:
0.176
Beta (Num):
-0.112
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.052
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism

Denominator Metabolite Explanation:

Fatty acid biosynthesis/metabolism

Ratio Explanation:

This ratio reflects the activity of Stearoyl-CoA Desaturase (SCD), which converts saturated fatty acids like caprate (or its elongated form) to monounsaturated ones like 5-dodecenoate.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in SCD alters its enzymatic activity, impacting the balance of saturated to monounsaturated fatty acids.3[1] This dyslipidemia is a known risk factor for the associated phenotypes, including hypercholesterolemia, atherosclerosis, and coronary artery disease.4[2], 3[3], 5[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data