5-dodecenoate (12:1n7) to nonadecanoate (19:0)

Numerator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Denominator Metabolite

Structure of nonadecanoate (19:0)
Metabolite Accession: GCST90200451
Name: nonadecanoate (19:0)
Hmdb Id: HMDB0000772
Super Pathway: NA
Sub Pathway: NA
Inchikey: ISYWECDDZWTKFF

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.160
Position:
102075479
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-9.238
Reference Allele:
G
-log10(P):
-45.129
MAF:
0.176
Beta (Num):
-0.112
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.048
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/desaturation

Denominator Metabolite Explanation:

Fatty acid metabolism/exogenous intake

Ratio Explanation:

This ratio likely reflects SCD enzyme activity, where 5-dodecenoate is an indirect product, against nonadecanoate, an exogenously derived fatty acid not impacted by SCD.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SCD, a key lipogenic enzyme, alter the ratio of 5-dodecenoate to nonadecanoate.1[1] This altered lipid profile is associated with an increased risk for atherosclerosis, hypercholesterolemia, and myocardial infarction.3[2], 4[3], 5[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data