5-dodecenoate (12:1n7) to pentadecanoate (15:0)

Numerator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
-0.154
Position:
102075479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-10.663
Reference Allele:
G
-log10(P):
-59.456
MAF:
0.176
Beta (Num):
-0.112
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.042
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio of 5-dodecenoate (unsaturated) to pentadecanoate (saturated) reflects the activity of desaturase enzymes like SCD, which is central to lipid metabolism.1[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered SCD gene function can change the ratio of unsaturated to saturated fatty acids, a process linked to disorders of lipoprotein metabolism and increased risk for atherosclerosis and myocardial infarction.1[1], 7[2], 8[3], 9[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data