1-oleoyl-gpc (18:1) to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-oleoyl-gpc (18:1)
Metabolite Accession: GCST90199727
Name: 1-oleoyl-gpc (18:1)
Hmdb Id: HMDB0002815
Super Pathway: NA
Sub Pathway: NA
Inchikey: YAMUFBLWGFFICM

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.118
Position:
61557803
SE (Ratio):
0.012
Effect Allele:
C
Z-score (Ratio):
-9.778
Reference Allele:
T
-log10(P):
-50.325
MAF:
0.346
Beta (Num):
0.003
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.121
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid metabolism.4[1], 5[2], 7[3]

Ratio Explanation:

This ratio reflects the balance between monounsaturated (from 1-oleoyl-gpc) and polyunsaturated (from 1-linoleoyl-gpc) fatty acid pools, which is influenced by FADS enzyme activity.1[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variations in FADS1/FADS2 genes alter the enzymatic conversion of fatty acids, affecting the oleoyl-GPC to linoleoyl-GPC ratio. This imbalance impacts lipid profiles and is linked to hypercholesterolemia, type 2 diabetes, and other metabolic disorders.2[1], 9[2], 10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data