10-nonadecenoate (19:1n9) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.114
Position:
102075479
SE (Ratio):
0.009
Effect Allele:
A
Z-score (Ratio):
12.020
Reference Allele:
G
-log10(P):
-74.965
MAF:
0.176
Beta (Num):
-0.015
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism

Denominator Metabolite Explanation:

Fatty Acid Biosynthesis

Ratio Explanation:

This ratio reflects the activity of Stearoyl-CoA Desaturase (SCD).1[1], 3[2] SCD synthesizes palmitoleate (denominator) and its activity is linked to various metabolic diseases.1[3], 4[4], 3[5]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SCD activity, indicated by the ratio, is associated with protection from obesity and improved insulin sensitivity, potentially explaining the link to a lower risk of myocardial infarction, hypercholesterolemia, and other cardiometabolic diseases.1[1], 3[2], 5[3]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data