10-nonadecenoate (19:1n9) to palmitate (16:0)

Numerator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.061
Position:
102075479
SE (Ratio):
0.008
Effect Allele:
A
Z-score (Ratio):
-7.940
Reference Allele:
G
-log10(P):
-33.837
MAF:
0.176
Beta (Num):
-0.015
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.046
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis

Denominator Metabolite Explanation:

Fatty acid biosynthesis4[1], 5[2]

Ratio Explanation:

The ratio of 10-nonadecenoate to palmitate reflects the activity of stearoyl-CoA desaturase (SCD), which is involved in converting saturated fatty acids like palmitate into monounsaturated fatty acids.1[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered SCD activity, influenced by genetic factors, affects the balance of saturated and unsaturated fatty acids.6[1], 7[2] This imbalance is associated with dyslipidemia and an increased risk of coronary atherosclerosis, myocardial infarction, and other cardiometabolic diseases.7[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data