10-nonadecenoate (19:1n9) to margarate (17:0)

Numerator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Denominator Metabolite

Structure of margarate (17:0)
Metabolite Accession: GCST90200459
Name: margarate (17:0)
Hmdb Id: HMDB0002259
Super Pathway: NA
Sub Pathway: NA
Inchikey: KEMQGTRYUADPNZ

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.090
Position:
102075479
SE (Ratio):
0.007
Effect Allele:
A
Z-score (Ratio):
-13.076
Reference Allele:
G
-log10(P):
-88.298
MAF:
0.176
Beta (Num):
-0.015
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.076
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/desaturation.1[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of 10-nonadecenoate to margarate may reflect SCD activity, where the enzyme produces the monounsaturated numerator from a saturated fatty acid precursor.1[1], 3[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered SCD activity, reflected by the fatty acid ratio, influences lipid composition and is associated with cardiometabolic diseases like atherosclerosis, hypercholesterolemia, and hypertension.2[1], 9[2], 10[3] SCD is also linked to a higher risk of gallstones due to its role in lipid metabolism.11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data