myristoylcarnitine (c14) to 3-hydroxyoctanoate

Numerator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Denominator Metabolite

Structure of 3-hydroxyoctanoate
Metabolite Accession: GCST90199680
Name: 3-hydroxyoctanoate
Hmdb Id: HMDB0001954
Super Pathway: NA
Sub Pathway: NA
Inchikey: NDPLAKGOSZHTPH

Associated Genomic Regions

Region: rs6695324

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.157
Position:
151926762
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
9.318
Reference Allele:
A
-log10(P):
-45.878
MAF:
0.316
Beta (Num):
0.041
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.116
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid transport, beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Mitochondrial fatty acid beta-oxidation.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio may reflect the balance of fatty acid import versus beta-oxidation activity, potentially modulated by THEM4's regulation of acyl-CoA pools.1[1], 3[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic regulation of THEM4 likely alters the balance between fatty acid transport and beta-oxidation, as reflected in the myristoylcarnitine to 3-hydroxyoctanoate ratio. However, no associated phenotype was provided, precluding the establishment of a causal link to a clinical outcome.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data