myristoylcarnitine (c14) to 3-hydroxydecanoate

Numerator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.247
Position:
151879761
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
16.174
Reference Allele:
G
-log10(P):
-133.814
MAF:
0.318
Beta (Num):
0.037
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.210
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

This ratio compares mitochondrial import of myristate (myristoylcarnitine) to a beta-oxidation intermediate (3-hydroxydecanoate), potentially modulated by THEM4 activity on acyl-CoA pools.9[1], 1[2], 5[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic factors, particularly THEM4, likely modulate fatty acid metabolism by altering the myristoyl-CoA pool, affecting the myristoylcarnitine to 3-hydroxydecanoate ratio. A link to a clinical phenotype is not established.1[1], 3[2]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data