10-heptadecenoate (17:1n7) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
0.072
Position:
102075479
SE (Ratio):
0.006
Effect Allele:
A
Z-score (Ratio):
12.350
Reference Allele:
G
-log10(P):
-79.008
MAF:
0.176
Beta (Num):
-0.056
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis and elongation.

Denominator Metabolite Explanation:

Fatty acid biosynthesis and desaturation.1[1]

Ratio Explanation:

This ratio may reflect fatty acid elongase activity, where palmitoleate (16:1n7) is elongated to 10-heptadecenoate (17:1n7), relative to SCD-mediated desaturation.3[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

SCD gene variants are linked to coronary artery disease.5[1] Altered SCD activity likely modifies the fatty acid profile, including this ratio, contributing to dyslipidemia and atherosclerosis, which are key factors in coronary atherosclerosis and myocardial infarction.6[2], 5[3], 7[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data