10-heptadecenoate (17:1n7) to stearate (18:0)

Numerator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.153
Position:
102075479
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
-13.846
Reference Allele:
G
-log10(P):
-98.713
MAF:
0.176
Beta (Num):
-0.056
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, long-chain fatty acid metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, saturated fatty acid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects Stearoyl-CoA Desaturase (SCD) activity, which influences the balance between saturated fatty acids like stearate and monounsaturated fatty acids like 10-heptadecenoate.9[1], 10[2], 11[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in SCD alter its desaturase activity, impacting the balance of saturated and monounsaturated fatty acids.1[1], 12[2] This dysregulation of lipid metabolism is linked to hypercholesterolemia and atherosclerosis, major risk factors for the associated cardiovascular diseases like myocardial infarction.13[3], 14[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data