10-heptadecenoate (17:1n7) to pentadecanoate (15:0)

Numerator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.098
Position:
102075479
SE (Ratio):
0.010
Effect Allele:
A
Z-score (Ratio):
-10.131
Reference Allele:
G
-log10(P):
-53.871
MAF:
0.176
Beta (Num):
-0.056
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.042
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis

Denominator Metabolite Explanation:

Fatty acid metabolism

Ratio Explanation:

The ratio of 10-heptadecenoate (17:1n7) to pentadecanoate (15:0) reflects the enzymatic activity of Stearoyl-CoA Desaturase (SCD), converting the saturated fatty acid to a monounsaturated one.2[1], 3[2], 4[3]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Altered SCD activity, indicated by the fatty acid ratio, is associated with dyslipidemia and increased risk of coronary atherosclerosis.5[1], 6[2], 7[3] Genetic variants in SCD are linked to changes in cholesterol levels and coronary artery disease risk.8[4], 5[5] The associated phenotypes like hypercholesterolemia and myocardial infarction reflect disruptions in lipid metabolism where SCD plays a crucial role.9[6], 10[7]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data