1-palmitoyl-gpc (16:0) to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-palmitoyl-gpc (16:0)
Metabolite Accession: GCST90199733
Name: 1-palmitoyl-gpc (16:0)
Hmdb Id: HMDB0010382
Super Pathway: NA
Sub Pathway: NA
Inchikey: ASWBNKHCZGQVJV

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174554

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.190
Position:
61579463
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
-12.171
Reference Allele:
A
-log10(P):
-76.801
MAF:
0.337
Beta (Num):
-0.064
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.127
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs1532624

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.122
Position:
57005479
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-8.164
Reference Allele:
C
-log10(P):
-35.667
MAF:
0.440
Beta (Num):
-0.054
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.068
SE (Den):
0.015
No CNV overlap
rQTL cluster:
26
Reaction Distance:
NA
Closest Genes:
CETP NLRC5 HERPUD1 SLC12A3 CPNE2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Lysolipid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.7[1], 8[2]

Ratio Explanation:

The ratio of a saturated (16:0) to a polyunsaturated (18:2) lysophosphatidylcholine reflects the balance between different fatty acid pools, influenced by FADS desaturase activity.9[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters the balance of saturated and polyunsaturated fatty acids, affecting membrane fluidity, inflammation, and lipoprotein metabolism.11[1], 9[2], 12[3], 13[4] This dysregulation is linked to an increased risk for cholelithiasis, dyslipidemia, and inflammatory conditions.13[5], 14[6], 15[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data