gamma-glutamylglycine to glycine

Numerator Metabolite

Structure of gamma-glutamylglycine
Metabolite Accession: GCST90199741
Name: gamma-glutamylglycine
Hmdb Id: HMDB0011667
Super Pathway: NA
Sub Pathway: NA
Inchikey: ACIJGUBIMXQCMF

Denominator Metabolite

Structure of glycine
Metabolite Accession: GCST90200707
Name: glycine
Hmdb Id: HMDB0000123
Super Pathway: NA
Sub Pathway: NA
Inchikey: DHMQDGOQFOQNFH

Associated Genomic Regions

Region: rs11075290

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.069
Position:
16098379
SE (Ratio):
0.009
Effect Allele:
C
Z-score (Ratio):
-7.976
Reference Allele:
T
-log10(P):
-34.122
MAF:
0.403
Beta (Num):
-0.060
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.009
SE (Den):
0.015
No CNV overlap
rQTL cluster:
33
Reaction Distance:
NA
Closest Genes:
ABCC1 FOPNL ABCC6 MYH11 NOMO3

LLM Analysis

Numerator Metabolite Explanation:

Glutathione metabolism, Dipeptide metabolism

Denominator Metabolite Explanation:

Reductive glycine pathway, Glycine and serine metabolism.4[1], 5[2], 6[3]

Ratio Explanation:

Gamma-glutamylglycine is formed from glutamate and glycine.7[1] ABCC1 can transport glutathione-conjugated substances, which may indirectly influence the availability of glycine and its derivatives.8[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype is associated. The ABCC1 gene, which has eQTL colocalization with the metabolite ratio, encodes a transporter protein involved in moving a variety of molecules, including glutathione conjugates, across cell membranes.1[1], 2[2], 10[3] This transport function could influence intracellular levels of substrates for gamma-glutamylglycine synthesis.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data