1-linoleoyl-gpc (18:2) to glycerophosphorylcholine (gpc)

Numerator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Denominator Metabolite

Structure of glycerophosphorylcholine (gpc)
Metabolite Accession: GCST90199629
Name: glycerophosphorylcholine (gpc)
Hmdb Id: HMDB0000086
Super Pathway: NA
Sub Pathway: NA
Inchikey: SUHOQUVVVLNYQR

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.184
Position:
61569830
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
12.292
Reference Allele:
C
-log10(P):
-78.286
MAF:
0.339
Beta (Num):
0.129
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.055
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Choline metabolism3[1], 4[2]

Ratio Explanation:

The ratio of 1-linoleoyl-GPC to GPC may reflect FADS activity, where FADS enzymes metabolize linoleic acid, a precursor to the numerator, while GPC is a downstream product.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 and FADS2, which alters PUFA metabolism5[1], 6[2], is linked to various inflammatory and cardiovascular phenotypes. The altered ratio likely reflects this dysregulated lipid metabolism, contributing to disease risk, including cholelithiasis and valvular heart disease.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data