1-linoleoyl-gpc (18:2) to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.373
Position:
61569830
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
17.574
Reference Allele:
C
-log10(P):
-157.520
MAF:
0.339
Beta (Num):
0.129
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.244
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleic acid metabolism.3[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Inositol phosphate metabolism.4[1], 5[2]

Ratio Explanation:

This ratio reflects FADS-mediated conversion of linoleic acid (18:2, precursor) to arachidonic acid (20:4, product) within different phospholipid classes.1[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants alter the conversion of linoleic acid (18:2) to arachidonic acid (20:4), impacting the balance of pro-inflammatory and anti-inflammatory molecules.7[1], 8[2] This dysregulation of lipid mediators contributes to the pathophysiology of associated inflammatory and metabolic disorders like cholelithiasis and hypercholesterolemia.1[3], 9[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data