eicosenoate (20:1) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of eicosenoate (20:1)
Metabolite Accession: GCST90199744
Name: eicosenoate (20:1)
Hmdb Id: HMDB0002231,HMDB0062436
Super Pathway: NA
Sub Pathway: NA
Inchikey: BITHHVVYSMSWAG

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.132
Position:
102075479
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
10.846
Reference Allele:
G
-log10(P):
-61.436
MAF:
0.176
Beta (Num):
0.004
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/elongation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid desaturation.1[1], 2[2], 5[3]

Ratio Explanation:

This ratio may reflect fatty acid elongation activity downstream of SCD, as palmitoleate (16:1n7) is elongated to produce eicosenoate (20:1).4[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered SCD activity, reflected by the eicosenoate to palmitoleate ratio, impacts lipid metabolism.6[1], 7[2] This dysregulation is associated with hypercholesterolemia and the development of atherosclerosis, leading to ischemic heart disease and myocardial infarction.8[3]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data