eicosenoate (20:1) to stearate (18:0)

Numerator Metabolite

Structure of eicosenoate (20:1)
Metabolite Accession: GCST90199744
Name: eicosenoate (20:1)
Hmdb Id: HMDB0002231,HMDB0062436
Super Pathway: NA
Sub Pathway: NA
Inchikey: BITHHVVYSMSWAG

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.093
Position:
102075479
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
-8.545
Reference Allele:
G
-log10(P):
-38.896
MAF:
0.176
Beta (Num):
0.004
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis and elongation.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.9[1], 10[2]

Ratio Explanation:

The ratio reflects the activity of the SCD enzyme, which converts stearate (18:0) to oleate (18:1), a precursor for eicosenoate (20:1) synthesis.1[1], 4[2], 7[3], 8[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced SCD activity can lead to an altered eicosenoate/stearate ratio, which is associated with an increased risk of myocardial infarction, ischemic heart disease, and hypertension.11[1], 12[2], 13[3]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data