erythronate* to erythritol

Numerator Metabolite

Structure of erythronate*
Metabolite Accession: GCST90199746
Name: erythronate*
Hmdb Id: HMDB0000613
Super Pathway: NA
Sub Pathway: NA
Inchikey: JPIJQSOTBSSVTP

Denominator Metabolite

Structure of erythritol
Metabolite Accession: GCST90199667
Name: erythritol
Hmdb Id: HMDB0002994
Super Pathway: NA
Sub Pathway: NA
Inchikey: UNXHWFMMPAWVPI

Associated Genomic Regions

Region: rs72690839

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.350
Position:
46246120
SE (Ratio):
0.027
Effect Allele:
T
Z-score (Ratio):
12.893
Reference Allele:
G
-log10(P):
-85.908
MAF:
0.053
Beta (Num):
0.017
Novel Locus:
No
SE (Num):
0.031
Beta (Den):
-0.332
SE (Den):
0.032
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
MAST2 IPP TMEM69 GPBP1L1 CCDC17

LLM Analysis

Numerator Metabolite Explanation:

Pentose phosphate pathway.7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

Pentose phosphate pathway.11[1], 12[2], 13[3], 14[4], 10[5], 15[6]

Ratio Explanation:

The erythronate to erythritol ratio reflects the metabolic conversion of erythritol to erythronate, a process that can be influenced by factors like diet and genetics.16[1], 17[2], 18[3], 10[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The missense variant in AKR1A1 could alter its activity in reducing aldehydes, potentially impacting the balance between erythritol and erythronate which are both linked to the pentose phosphate pathway; however, no associated phenotype is provided.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data