linolenate [alpha or gamma; (18:3n3 or 6)] to palmitoleate (16:1n7)

Numerator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.160
Position:
102075479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
11.483
Reference Allele:
G
-log10(P):
-68.608
MAF:
0.176
Beta (Num):
0.032
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism

Denominator Metabolite Explanation:

De novo lipogenesis, Fatty acid biosynthesis

Ratio Explanation:

The ratio of linolenate to palmitoleate reflects the balance between dietary polyunsaturated fatty acids and endogenously synthesized monounsaturated fatty acids by SCD.3[1], 4[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation near the SCD gene alters its activity, impacting the ratio of essential to de novo synthesized fatty acids.3[1], 4[2] This lipid imbalance is associated with hypercholesterolemia, cholelithiasis, and coronary atherosclerosis, key risk factors for myocardial infarction.5[3], 6[4], 7[5]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data