laurylcarnitine to palmitoylcarnitine (c16)

Numerator Metabolite

Structure of laurylcarnitine (c12)
Metabolite Accession: GCST90199750
Name: laurylcarnitine (c12)
Hmdb Id: HMDB000225
Super Pathway: NA
Sub Pathway: NA
Inchikey: FUJLYHJROOYKRA

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs17843929

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
-0.122
Position:
159637113
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
-8.161
Reference Allele:
C
-log10(P):
-35.639
MAF:
0.264
Beta (Num):
-0.092
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.031
SE (Den):
0.017
No CNV overlap
rQTL cluster:
118
Reaction Distance:
NA
Closest Genes:
PPID ETFDH C4orf46 FNIP2 RXFP1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.6[1], 7[2], 8[3], 9[4], 10[5]

Denominator Metabolite Explanation:

Fatty acid metabolism.11[1], 12[2], 13[3]

Ratio Explanation:

Elevated laurylcarnitine/palmitoylcarnitine ratio may indicate impaired fatty acid oxidation, as ETFDH dysfunction can cause accumulation of various length acylcarnitines, altering their relative abundance.14[1], 15[2], 16[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype was provided in the input data, so no link between the ratio and a phenotype can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data