laurylcarnitine to 3-hydroxyoctanoate

Numerator Metabolite

Structure of laurylcarnitine (c12)
Metabolite Accession: GCST90199750
Name: laurylcarnitine (c12)
Hmdb Id: HMDB000225
Super Pathway: NA
Sub Pathway: NA
Inchikey: FUJLYHJROOYKRA

Denominator Metabolite

Structure of 3-hydroxyoctanoate
Metabolite Accession: GCST90199680
Name: 3-hydroxyoctanoate
Hmdb Id: HMDB0001954
Super Pathway: NA
Sub Pathway: NA
Inchikey: NDPLAKGOSZHTPH

Associated Genomic Regions

Region: rs6695324

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.161
Position:
151926762
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
9.762
Reference Allele:
A
-log10(P):
-50.161
MAF:
0.316
Beta (Num):
0.044
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.116
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism

Denominator Metabolite Explanation:

Fatty acid metabolism.4[1]

Ratio Explanation:

An elevated laurylcarnitine to 3-hydroxyoctanoate ratio may indicate altered fatty acid metabolism, potentially influenced by THEM4's role in acyl-CoA hydrolysis.1[1], 2[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The eQTL colocalization for THEM4, an acyl-CoA thioesterase, suggests a potential link between its function in fatty acid metabolism and the observed metabolite ratio, but no direct phenotype has been established.

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data