laurylcarnitine to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of laurylcarnitine (c12)
Metabolite Accession: GCST90199750
Name: laurylcarnitine (c12)
Hmdb Id: HMDB000225
Super Pathway: NA
Sub Pathway: NA
Inchikey: FUJLYHJROOYKRA

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs971887

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.108
Position:
151943497
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
8.396
Reference Allele:
G
-log10(P):
-37.610
MAF:
0.333
Beta (Num):
0.045
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.063
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 TCHHL1 THEM5

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.148
Position:
102075479
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
9.353
Reference Allele:
G
-log10(P):
-46.210
MAF:
0.176
Beta (Num):
0.036
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.112
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Carnitine shuttle

Denominator Metabolite Explanation:

Fatty acid biosynthesis, Fatty acid beta-oxidation3[1]

Ratio Explanation:

The ratio reflects Stearoyl-CoA Desaturase (SCD) activity, converting saturated C12:0 (laurylcarnitine precursor) to monounsaturated C12:1 (5-dodecenoate).

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Reduced SCD activity alters the saturated/monounsaturated fatty acid balance, a known contributor to lipid metabolism disorders, hypercholesterolaemia, and atherosclerosis.2[1], 4[2], 5[3], 6[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data