phenylacetylglutamine to phenylacetate

Numerator Metabolite

Structure of phenylacetylglutamine
Metabolite Accession: GCST90199768
Name: phenylacetylglutamine
Hmdb Id: HMDB0006344
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFLIEFSWGNOPJJ

Denominator Metabolite

Structure of phenylacetate
Metabolite Accession: GCST90199630
Name: phenylacetate
Hmdb Id: HMDB0000209
Super Pathway: NA
Sub Pathway: NA
Inchikey: WLJVXDMOQOGPHL

Associated Genomic Regions

Region: rs77863699

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.470
Position:
20563528
SE (Ratio):
0.042
Effect Allele:
C
Z-score (Ratio):
-11.174
Reference Allele:
T
-log10(P):
-65.073
MAF:
0.024
Beta (Num):
-0.030
Novel Locus:
No
SE (Num):
0.048
Beta (Den):
0.440
SE (Den):
0.052
No CNV overlap
rQTL cluster:
28
Reaction Distance:
NA
Closest Genes:
ACSM2B ACSM3 AC137056.1 ACSM2A ACSM1

Region: rs11642648

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.274
Position:
20610955
SE (Ratio):
0.036
Effect Allele:
A
Z-score (Ratio):
-7.520
Reference Allele:
G
-log10(P):
-30.534
MAF:
0.032
Beta (Num):
-0.047
Novel Locus:
No
SE (Num):
0.041
Beta (Den):
0.226
SE (Den):
0.046
No CNV overlap
rQTL cluster:
29
Reaction Distance:
NA
Closest Genes:
ACSM3 ACSM2B ACSM1 AC137056.1 ACSM2A

LLM Analysis

Numerator Metabolite Explanation:

Phenylalanine metabolism, nitrogen excretion.4[1], 5[2]

Denominator Metabolite Explanation:

Phenylalanine metabolism, xenobiotic detoxification.2[1], 6[2]

Ratio Explanation:

This ratio indicates the efficiency of converting phenylacetate (denominator) to phenylacetylglutamine (numerator) for detoxification.2[1], 7[2] A lower ratio may suggest reduced ACSM2B activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data