1-arachidonylglycerol (20:4) to 1-linoleoylglycerol (18:2)

Numerator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Denominator Metabolite

Structure of 1-linoleoylglycerol (18:2)
Metabolite Accession: GCST90199684
Name: 1-linoleoylglycerol (18:2)
Hmdb Id: HMDB0011568
Super Pathway: NA
Sub Pathway: NA
Inchikey: WECGLUPZRHILCT

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.283
Position:
61570783
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
-18.805
Reference Allele:
T
-log10(P):
-179.985
MAF:
0.333
Beta (Num):
-0.266
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.017
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis, Endocannabinoid signaling.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.6[1], 7[2]

Ratio Explanation:

The ratio of 1-arachidonylglycerol (20:4) to 1-linoleoylglycerol (18:2) reflects the desaturation efficiency of linoleic acid to arachidonic acid by FADS1/FADS2 enzymes.8[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter the efficiency of PUFA synthesis, impacting the balance of pro-inflammatory lipids derived from arachidonic acid.10[1], 11[2], 12[3] This influences lipid metabolism and inflammatory responses, contributing to phenotypes like dyslipidemia, asthma, and inflammatory bowel disease.13[4], 10[5], 11[6], 12[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data