1-arachidonylglycerol (20:4) to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.549
Position:
61588305
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
-23.341
Reference Allele:
A
-log10(P):
-275.776
MAF:
0.337
Beta (Num):
-0.271
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.278
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Endocannabinoid signaling.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects the activity of FADS1/FADS2, where higher activity leads to more 1-arachidonylglycerol (20:4) relative to its precursor substrate 1-linoleoyl-gpe (18:2).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter enzyme activity, impacting the conversion of linoleic acid to arachidonic acid, a key process in inflammation and lipid metabolism.2[1], 9[2] This is linked to phenotypes like cholelithiasis and type 2 diabetes, potentially through altered inflammatory responses and lipid profiles.10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data