1-stearoyl-gpe (18:0) to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.199
Position:
61557803
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
-12.815
Reference Allele:
T
-log10(P):
-84.893
MAF:
0.346
Beta (Num):
-0.078
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.121
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis.10[1], 11[2], 12[3], 13[4]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.14[1], 15[2]

Ratio Explanation:

The ratio reflects the relative activity of fatty acid desaturase enzymes (FADS1/FADS2), where genetic variants influence the conversion of linoleic acid to other polyunsaturated fatty acids.16[1], 17[2], 18[3], 19[4], 20[5]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster are associated with altered FADS1/FADS2 enzyme activity, which affects the balance of polyunsaturated fatty acids.16[1], 18[2], 19[3], 20[4], 21[5] This dysregulation of lipid metabolism, particularly impacting cholesterol levels, is linked to an increased risk for pure hypercholesterolaemia and other related cardiometabolic phenotypes.16[6], 17[7], 19[8], 22[9], 23[10]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data