oleoylcarnitine (c18:1) to palmitoylcarnitine (c16)

Numerator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.124
Position:
102075479
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-8.127
Reference Allele:
G
-log10(P):
-35.364
MAF:
0.176
Beta (Num):
-0.071
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.053
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation5[1], 4[2]

Ratio Explanation:

The ratio of oleoylcarnitine (C18:1) to palmitoylcarnitine (C16) reflects the activity of SCD, which converts stearoyl-CoA (precursor to C18:1) from palmitoyl-CoA (precursor to C16).1[1], 2[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Increased SCD activity, reflected by a higher oleoylcarnitine to palmitoylcarnitine ratio, is associated with an elevated risk of cardiovascular diseases like coronary atherosclerosis and myocardial infarction.6[1], 7[2] Altered fatty acid metabolism may contribute to these conditions.6[3], 8[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data