oleoylcarnitine (c18:1) to 3-hydroxydecanoate

Numerator Metabolite

Metabolite Accession: GCST90199774

Name: NA

Hmdb Id: NA

Super Pathway: NA

Sub Pathway: NA

Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199693

Name: 3-hydroxydecanoate

Hmdb Id: HMDB0002203

Super Pathway: NA

Sub Pathway: NA

Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:

Beta (Ratio):

0.249

Position:

151879761

SE (Ratio):

0.016

Effect Allele:

Z-score (Ratio):

15.335

Reference Allele:

-log10(P):

-120.545

MAF:

0.318

Beta (Num):

0.039

Novel Locus:

SE (Num):

0.016

Beta (Den):

-0.210

SE (Den):

0.016

No CNV overlap

rQTL cluster:

155

Reaction Distance:

Closest Genes:

THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation, carnitine shuttle.4^[1], 5^[2], 6^[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.7^[1], 8^[2]

Ratio Explanation:

The ratio reflects the balance between long-chain fatty acid import/availability (oleoylcarnitine) and medium-chain fatty acid beta-oxidation flux (3-hydroxydecanoate), potentially influenced by peroxisomal metabolism via THEM4.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype was provided, so a link between the THEM4 gene, the oleoylcarnitine to 3-hydroxydecanoate ratio, and a clinical outcome cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data