oleoylcarnitine (c18:1) to stearate (18:0)

Numerator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.167
Position:
102075479
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-8.338
Reference Allele:
G
-log10(P):
-37.120
MAF:
0.176
Beta (Num):
-0.071
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.5[1], 7[2], 8[3]

Ratio Explanation:

The ratio of oleoylcarnitine (c18:1) to stearate (18:0) directly reflects the enzymatic activity of Stearoyl-CoA Desaturase (SCD), a key enzyme in fatty acid metabolism.1[1], 3[2], 9[3]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variants impacting SCD (Stearoyl-CoA Desaturase) activity alter the balance of fatty acids, which is implicated in the pathogenesis of associated cardiometabolic phenotypes like coronary atherosclerosis and hypercholesterolemia.1[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data