1-stearoyl-gpg (18:0) to 2-palmitoleoyl-gpc (16:1)*

Numerator Metabolite

Structure of 1-stearoyl-gpg (18:0)
Metabolite Accession: GCST90199780
Name: 1-stearoyl-gpg (18:0)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: HFJVKBVEKQHVTO

Denominator Metabolite

Structure of 2-palmitoleoyl-gpc (16:1)*
Metabolite Accession: GCST90199790
Name: 2-palmitoleoyl-gpc (16:1)*
Hmdb Id: HMDB10383
Super Pathway: NA
Sub Pathway: NA
Inchikey: GKXPPJQBVCKAGD

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.231
Position:
102075479
SE (Ratio):
0.026
Effect Allele:
A
Z-score (Ratio):
8.939
Reference Allele:
G
-log10(P):
-42.385
MAF:
0.179
Beta (Num):
0.085
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
-0.146
SE (Den):
0.022
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Cardiolipin Biosynthesis.3[1]

Denominator Metabolite Explanation:

Phosphatidylcholine Biosynthesis, Glycerophospholipid metabolism.4[1], 5[2]

Ratio Explanation:

The ratio reflects SCD enzyme activity, converting saturated fatty acids like stearic acid (18:0) to monounsaturated ones like palmitoleic acid (16:1).6[1], 7[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Reduced SCD activity, indicated by a higher ratio, is linked to altered lipid profiles, including lower levels of monounsaturated fatty acids. This dyslipidemia is associated with an increased risk of coronary atherosclerosis, hypercholesterolemia, and myocardial infarction.8[1], 9[2]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data