1-arachidonoyl-gpc (20:4n6)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-arachidonoyl-gpc (20:4n6)*
Metabolite Accession: GCST90199788
Name: 1-arachidonoyl-gpc (20:4n6)*
Hmdb Id: HMDB0010395
Super Pathway: NA
Sub Pathway: NA
Inchikey: LAXQYRRMGGEGOH

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174533

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.684
Position:
61549025
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-38.357
Reference Allele:
G
-log10(P):
-739.504
MAF:
0.337
Beta (Num):
-0.561
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.123
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.5[1]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.5[1]

Ratio Explanation:

The ratio reflects the enzymatic conversion of the denominator (1-linoleoyl-gpc) to the numerator (1-arachidonoyl-gpc), a key step in polyunsaturated fatty acid metabolism.6[1], 7[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter desaturase activity, influencing the ratio of 1-arachidonoyl-gpc to 1-linoleoyl-gpc.1[1], 8[2], 9[3] This altered lipid profile is associated with dyslipidemia and an increased risk of cardiovascular diseases.8[4], 10[5], 11[6], 12[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data