1-arachidonoyl-gpc (20:4n6)* to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Structure of 1-arachidonoyl-gpc (20:4n6)*
Metabolite Accession: GCST90199788
Name: 1-arachidonoyl-gpc (20:4n6)*
Hmdb Id: HMDB0010395
Super Pathway: NA
Sub Pathway: NA
Inchikey: LAXQYRRMGGEGOH

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174533

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.839
Position:
61549025
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
-40.469
Reference Allele:
G
-log10(P):
-822.795
MAF:
0.337
Beta (Num):
-0.561
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.278
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Arachidonic acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleic acid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of 1-arachidonoyl-gpc to 1-linoleoyl-gpe reflects the enzymatic activity of FADS1 and FADS2, which convert linoleic acid to arachidonic acid.1[1], 2[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid balance, reflected in the ratio.9[1], 2[2], 10[3] This dysregulation of lipid metabolism is causally linked by MR and colocalization data to hypercholesterolemia, lipoprotein disorders, and related conditions like cholelithiasis.9[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data