1-arachidonoyl-gpe (20:4n6)* to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of 1-arachidonoyl-gpe (20:4n6)*
Metabolite Accession: GCST90199791
Name: 1-arachidonoyl-gpe (20:4n6)*
Hmdb Id: HMDB0011517
Super Pathway: NA
Sub Pathway: NA
Inchikey: ROPRRXYVXLDXQO

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs626283

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.225
Position:
54677001
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
13.650
Reference Allele:
G
-log10(P):
-96.002
MAF:
0.439
Beta (Num):
0.051
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.174
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
TMC4 MBOAT7 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid signaling.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylinositol signaling pathway.6[1], 7[2]

Ratio Explanation:

The ratio of a lysophosphatidylethanolamine to a phosphatidylinositol may reflect lipid remodeling activity, but the specific involvement of TMC4 is not established.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants near TMC4 are associated with altered levels of liver enzymes and platelet counts.8[1], 9[2] The TMC4 gene's primary function as an ion channel does not directly explain the metabolic ratio, suggesting a complex or indirect link to the observed phenotypes.1[3], 2[4], 10[5]

Phenotype Driver:

Gene-centric:TMC4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data