1-arachidonoyl-gpe (20:4n6)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-arachidonoyl-gpe (20:4n6)*
Metabolite Accession: GCST90199791
Name: 1-arachidonoyl-gpe (20:4n6)*
Hmdb Id: HMDB0011517
Super Pathway: NA
Sub Pathway: NA
Inchikey: ROPRRXYVXLDXQO

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.494
Position:
61557803
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-27.377
Reference Allele:
T
-log10(P):
-378.278
MAF:
0.345
Beta (Num):
-0.372
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.121
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.7[1]

Denominator Metabolite Explanation:

Fatty acid metabolism.8[1], 9[2]

Ratio Explanation:

The ratio reflects the conversion of linoleic acid (denominator) to arachidonic acid (numerator), a process catalyzed by FADS enzymes, including the genetically associated FADS1.1[1], 2[2], 3[3], 5[4], 7[5], 10[6]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, influenced by genetic factors, can lead to lower arachidonic acid relative to linoleic acid, which is associated with altered lipid profiles like hypercholesterolemia and an increased risk of cholelithiasis and other inflammatory conditions.11[1], 12[2], 13[3], 14[4], 15[5], 16[6], 17[7], 18[8], 19[9]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data