1-arachidonoyl-gpe (20:4n6)* to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Structure of 1-arachidonoyl-gpe (20:4n6)*
Metabolite Accession: GCST90199791
Name: 1-arachidonoyl-gpe (20:4n6)*
Hmdb Id: HMDB0011517
Super Pathway: NA
Sub Pathway: NA
Inchikey: ROPRRXYVXLDXQO

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174533

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.648
Position:
61549025
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-37.680
Reference Allele:
G
-log10(P):
-713.765
MAF:
0.338
Beta (Num):
-0.370
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.278
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.1[1], 2[2], 7[3], 14[4], 15[5]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.1[1], 2[2], 7[3], 16[4], 17[5]

Ratio Explanation:

The ratio reflects the enzymatic efficiency of FADS1 and FADS2 in converting linoleoyl-gpe to arachidonoyl-gpe, indicating the rate of polyunsaturated fatty acid metabolism.3[1], 8[2], 10[3], 13[4]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 are associated with altered levels of arachidonic and linoleic acid, influencing the risk for pure hypercholesterolaemia and benign colon neoplasms, likely through modulation of inflammatory pathways and lipid metabolism.8[1], 10[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data