1-palmitoyl-gpe (16:0) to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Structure of 1-palmitoyl-gpe (16:0)
Metabolite Accession: GCST90199792
Name: 1-palmitoyl-gpe (16:0)
Hmdb Id: HMDB0011503
Super Pathway: NA
Sub Pathway: NA
Inchikey: YVYMBNSKXOXSKW

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.302
Position:
61570783
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
-19.561
Reference Allele:
T
-log10(P):
-194.519
MAF:
0.339
Beta (Num):
-0.019
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.283
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid Biosynthesis.5[1]

Denominator Metabolite Explanation:

Phospholipid Biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio may reflect the relative activity of FADS2 on palmitic acid versus linoleic acid precursors, influencing the balance of saturated and polyunsaturated lysophosphatidylethanolamines.9[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, influenced by genetic factors, likely shifts the balance of fatty acid desaturation, impacting downstream lipid profiles and contributing to phenotypes like pure hypercholesterolaemia and cholelithiasis, which are linked to lipid metabolism disorders.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data