1-palmitoyl-gpe (16:0) to tryptophan

Numerator Metabolite

Structure of 1-palmitoyl-gpe (16:0)
Metabolite Accession: GCST90199792
Name: 1-palmitoyl-gpe (16:0)
Hmdb Id: HMDB0011503
Super Pathway: NA
Sub Pathway: NA
Inchikey: YVYMBNSKXOXSKW

Denominator Metabolite

Structure of tryptophan
Metabolite Accession: GCST90200441
Name: tryptophan
Hmdb Id: HMDB0000929
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIVBCDIJIAJPQS

Associated Genomic Regions

Region: rs56165099

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.207
Position:
21357731
SE (Ratio):
0.025
Effect Allele:
T
Z-score (Ratio):
8.295
Reference Allele:
C
-log10(P):
-36.763
MAF:
0.192
Beta (Num):
0.114
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.092
SE (Den):
0.019
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Tryptophan metabolism, Kynurenine pathway3[1], 4[2]

Ratio Explanation:

Reduced SLCO1B1 function may impair hepatic uptake of both tryptophan and 1-palmitoyl-GPE (16:0), potentially altering their ratio in circulation, though direct transport evidence is limited.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired SLCO1B1 function alters the transport of bilirubin and lipids, leading to hyperbilirubinemia (elevated TBil and MCV) and dyslipidemia (elevated triglycerides).1[1], 5[2], 6[3], 7[4] The relationship with the specific metabolite ratio is less direct than the gene's primary role in these phenotypes.

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data