1-linoleoyl-gpe (18:2)* to 1,2-dipalmitoyl-gpc (16:0/16:0)

Numerator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Denominator Metabolite

Structure of 1,2-dipalmitoyl-gpc (16:0/16:0)
Metabolite Accession: GCST90199660
Name: 1,2-dipalmitoyl-gpc (16:0/16:0)
Hmdb Id: HMDB0000564
Super Pathway: NA
Sub Pathway: NA
Inchikey: KILNVBDSWZSGLL

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.498
Position:
61570783
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
24.256
Reference Allele:
T
-log10(P):
-297.593
MAF:
0.339
Beta (Num):
0.283
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.215
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.5[1], 6[2], 7[3]

Ratio Explanation:

The ratio reflects FADS-mediated desaturation activity, where higher FADS function leads to more polyunsaturated fats like 1-linoleoyl-gpe (18:2) relative to saturated fats.8[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene variants are associated with altered FADS1/FADS2 expression and activity, which changes the balance of saturated and polyunsaturated fatty acids.10[1], 11[2] This shift is linked to conditions like pure hypercholesterolemia and inflammatory bowel disease, likely by affecting lipid metabolism and inflammatory pathways.12[3], 13[4], 14[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data