1-oleoyl-gpe (18:1) to 1-palmitoyl-gpc (16:0)

Numerator Metabolite

Structure of 1-oleoyl-gpe (18:1)
Metabolite Accession: GCST90199794
Name: 1-oleoyl-gpe (18:1)
Hmdb Id: HMDB0011506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PYVRVRFVLRNJLY

Denominator Metabolite

Structure of 1-palmitoyl-gpc (16:0)
Metabolite Accession: GCST90199733
Name: 1-palmitoyl-gpc (16:0)
Hmdb Id: HMDB0010382
Super Pathway: NA
Sub Pathway: NA
Inchikey: ASWBNKHCZGQVJV

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.144
Position:
61579463
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
8.062
Reference Allele:
A
-log10(P):
-34.825
MAF:
0.338
Beta (Num):
0.080
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.064
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

This ratio reflects the activity of fatty acid desaturase (FADS) enzymes, comparing a lysophospholipid with a monounsaturated fatty acid to one with a saturated fatty acid.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity impacts the balance of saturated and unsaturated fatty acids, influencing lipid profiles and inflammation.11[1], 12[2], 13[3] This is linked to phenotypes like hypercholesterolemia, cholelithiasis, and inflammatory diseases such as asthma.14[4], 15[5], 16[6], 17[7], 18[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data