docosapentaenoate (n6 dpa; 22:5n6) to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs174570

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.177
Position:
61597212
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
-10.337
Reference Allele:
C
-log10(P):
-56.001
MAF:
0.131
Beta (Num):
-0.162
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.015
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.7[1]

Ratio Explanation:

The ratio reflects FADS1/FADS2 enzyme activity, representing the synthesis of a downstream n-6 PUFA (22:5n6) relative to a monounsaturated odd-chain fatty acid.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS gene cluster alter enzyme activity, impacting circulating levels of polyunsaturated fatty acids.8[1], 9[2], 10[3] This dysregulation of lipid metabolism is associated with an increased risk for hypercholesterolemia, type 2 diabetes, and certain skin cancers.11[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data