docosapentaenoate (n6 dpa; 22:5n6) to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.242
Position:
61569830
SE (Ratio):
0.025
Effect Allele:
T
Z-score (Ratio):
-9.849
Reference Allele:
C
-log10(P):
-51.024
MAF:
0.340
Beta (Num):
-0.113
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis7[1], 8[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism9[1], 10[2]

Ratio Explanation:

The ratio of docosapentaenoate (n6 dpa) to 1-linoleoyl-gpc (18:2) reflects the efficiency of converting linoleic acid into longer, more unsaturated fatty acids by FADS enzymes.1[1], 2[2], 3[3], 4[4], 5[5], 6[6]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS activity, influenced by genetic factors, can alter the balance of pro-inflammatory and anti-inflammatory lipid mediators, potentially contributing to the risk of inflammatory conditions like inflammatory bowel disease and metabolic disorders such as type 2 diabetes and cholelithiasis.11[1], 12[2], 13[3], 14[4], 15[5], 16[6], 17[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data