docosapentaenoate (n6 dpa; 22:5n6) to eicosenoate (20:1)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Structure of eicosenoate (20:1)
Metabolite Accession: GCST90199744
Name: eicosenoate (20:1)
Hmdb Id: HMDB0002231,HMDB0062436
Super Pathway: NA
Sub Pathway: NA
Inchikey: BITHHVVYSMSWAG

Associated Genomic Regions

Region: rs174570

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.185
Position:
61597212
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
-9.878
Reference Allele:
C
-log10(P):
-51.313
MAF:
0.131
Beta (Num):
-0.162
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.023
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid elongation.6[1]

Ratio Explanation:

The ratio reflects FADS2 activity, which is crucial for converting precursors into docosapentaenoate (n6 dpa), while eicosenoate is part of a separate but related pathway.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS2 are associated with altered FADS2 activity, impacting the balance of polyunsaturated and monounsaturated fatty acids.7[1], 8[2] This altered lipid profile is linked to an increased risk for dyslipidemia, type 2 diabetes, and skin cancer.7[3], 9[4], 10[5], 11[6]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data