docosapentaenoate (n6 dpa; 22:5n6) to tetradecanedioate (c14-dc)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Associated Genomic Regions

Region: rs174565

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.227
Position:
61591636
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
-9.337
Reference Allele:
C
-log10(P):
-46.059
MAF:
0.131
Beta (Num):
-0.161
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.066
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

PUFA biosynthesis, Fatty acid metabolism

Denominator Metabolite Explanation:

Fatty acid omega-oxidation

Ratio Explanation:

This ratio likely reflects the activity of FADS2-mediated PUFA synthesis versus fatty acid degradation through omega-oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS2 gene variants influence PUFA levels, impacting inflammatory and metabolic processes.1[1] This altered lipid metabolism is associated with an increased risk for type 2 diabetes and skin cancer, where FADS2 is often overexpressed and promotes tumor progression.2[2], 3[3], 4[4], 5[5], 6[6], 7[7]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data