docosapentaenoate (n6 dpa; 22:5n6) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.151
Position:
102075479
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
10.187
Reference Allele:
G
-log10(P):
-54.444
MAF:
0.177
Beta (Num):
0.023
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs174570

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.164
Position:
61597212
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
-9.936
Reference Allele:
C
-log10(P):
-51.894
MAF:
0.131
Beta (Num):
-0.162
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.002
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid metabolism, PUFA biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, de novo lipogenesis.5[1], 6[2]

Ratio Explanation:

The ratio reflects FADS2 enzymatic activity, comparing long-chain omega-6 fatty acid production (docosapentaenoate) against monounsaturated fatty acid synthesis (palmitoleate).1[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS2 alters desaturase activity, impacting the balance of pro- and anti-inflammatory fatty acids.2[1], 7[2] This dysregulation of lipid metabolism contributes to hypercholesterolemia, atherosclerosis, and type 2 diabetes, which are among the observed phenotypes.8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data