docosapentaenoate (n6 dpa; 22:5n6) to stearate (18:0)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs174570

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.157
Position:
61597212
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
-9.138
Reference Allele:
C
-log10(P):
-44.205
MAF:
0.131
Beta (Num):
-0.162
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.006
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.5[1], 6[2], 7[3]

Ratio Explanation:

This ratio reflects the activity of FADS1/FADS2 enzymes, which synthesize docosapentaenoate (n6 dpa) from precursors related to stearate in the fatty acid synthesis pathway.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 genes alter desaturase activity, impacting the conversion of fatty acids and leading to changes in lipid profiles and inflammation.2[1], 8[2] This dysregulation is associated with an increased risk for type 2 diabetes and skin cancer.9[3], 10[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data