docosapentaenoate (n6 dpa; 22:5n6) to myristate (14:0)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Structure of myristate (14:0)
Metabolite Accession: GCST90200414
Name: myristate (14:0)
Hmdb Id: HMDB0000806
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUNFSRHWOTWDNC

Associated Genomic Regions

Region: rs174565

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.167
Position:
61591636
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
-9.014
Reference Allele:
C
-log10(P):
-43.062
MAF:
0.131
Beta (Num):
-0.161
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.006
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.7[1], 8[2]

Ratio Explanation:

The ratio reflects the efficiency of converting shorter-chain fatty acids to long-chain polyunsaturated fatty acids, a process catalyzed by FADS enzymes.3[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by an altered ratio, is linked to modified lipid profiles, including cholesterol levels, and an increased risk for hypercholesterolemia, cholelithiasis, and type 2 diabetes.9[1], 10[2], 11[3], 12[4], 13[5], 14[6], 15[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data