docosapentaenoate (n6 dpa; 22:5n6) to nonadecanoate (19:0)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Structure of nonadecanoate (19:0)
Metabolite Accession: GCST90200451
Name: nonadecanoate (19:0)
Hmdb Id: HMDB0000772
Super Pathway: NA
Sub Pathway: NA
Inchikey: ISYWECDDZWTKFF

Associated Genomic Regions

Region: rs174565

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.184
Position:
61591636
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
-9.014
Reference Allele:
C
-log10(P):
-43.067
MAF:
0.131
Beta (Num):
-0.161
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.024
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Fatty acid metabolism

Ratio Explanation:

This ratio likely reflects FADS desaturase activity, converting precursors into docosapentaenoate, relative to the unrelated odd-chain fatty acid nonadecanoate, which is often diet-derived.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants alter desaturase efficiency, impacting the ratio and polyunsaturated fatty acid levels. This dysregulation of lipid metabolism is associated with an increased risk for hypercholesterolemia, type 2 diabetes, and skin cancer, likely through inflammatory pathways and altered cell membrane composition.3[1], 4[2], 5[3], 6[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data