docosapentaenoate (n6 dpa; 22:5n6) to pentadecanoate (15:0)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.126
Position:
61588305
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-8.981
Reference Allele:
A
-log10(P):
-42.766
MAF:
0.345
Beta (Num):
-0.110
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.016
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism6[1], 7[2]

Ratio Explanation:

The ratio reflects FADS1/FADS2 desaturase activity converting precursors into docosapentaenoate (n6), relative to pentadecanoate, an odd-chain saturated fatty acid not synthesized by FADS.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter enzyme activity, impacting the docosapentaenoate/pentadecanoate ratio. This dysregulation of fatty acid profiles is linked to an increased risk for lipid-related disorders such as cholelithiasis, hypercholesterolemia, and type 2 diabetes, which are observed associated phenotypes.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data