octadecanedioate (c18-dc) to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of octadecanedioate (c18-dc)
Metabolite Accession: GCST90199805
Name: octadecanedioate (c18-dc)
Hmdb Id: HMDB0000782
Super Pathway: NA
Sub Pathway: NA
Inchikey: BNJOQKFENDDGSC

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs77420750

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.205
Position:
15979744
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-11.376
Reference Allele:
C
-log10(P):
-67.366
MAF:
0.297
Beta (Num):
-0.161
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.043
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H1 OR10H5 OR10H4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.6[1], 7[2]

Ratio Explanation:

The ratio reflects CYP4F2 activity; higher activity may increase octadecanedioate (omega-oxidation product) relative to other fatty acids like 10-nonadecenoate.2[1], 3[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced CYP4F2 activity, indicated by the missense variant, alters fatty acid and eicosanoid metabolism, which is linked to an increased risk of coronary atherosclerosis and ischemic heart disease.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data